- Title: The Binding of Isaac: Rebirth
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Heya fellow Isaac players, in this guide I’ll give a ranking on boss rush unlocks for non-tainted characters, with a difficulty rating and a value rating for how good the unlock is. Do note, this is a personal opinion, so if one of y’all thinks an unlock is better than I give it credit for, please do enlighten me as to why you think so!
Isaac: Isaac’s Head
Difficulty: 4/10
Isaac doesn’t really have issues with the boss rush, especially if D6 is unlocked.
Unlock rating: C
Useful early on due to its piercing, but the competition for the trinket slot is typically better
Maggy: Maggy’s bow
Difficulty: 5/10
Yum heart and red health makes surviving easier, but dps can be an issue.
Unlock value: A
Varies from character to character, but is typically pretty damn decent. Completely broken when playing as t. Maggy.
Cain: Cain’s other eye
Difficulty: 5/10
Basically the opposite of Maggy, good DPS, but questionable survivability.
Unlock value: D
A waste of a treasure pool item, in my opinion, nonexistent DPS and uncontrollable movement. At least peeper gives damage up!
Judas: Judas’ shadow
Difficulty: 2/10
Book of belial op, nuff said
Unlock value: A
A revive item that makes you judas with a 2x damage multiplier? Sign me up!
???: ???’s only friend
Difficulty: 7/10
??? having only soul hearts hurts a lot here, coz most bosses will only drop red health.
Unlock value: C
Nothing amazing, but I’d take it over a godamn stat upgrade. Also counts for Beelzebub so that’s nice.
Eve: Eve’s mascara
Difficulty: 5/10
Depends on whether Wob is being relied on, and even then, it shouldn’t be too hard.
Unlock value: A
Kind of a controversial unlock last time I checked, but I love it! Again I must say, I love me a damage multiplier!
Samson: Samson’s chains
Ok first off what the hell is up with the boss rush unlocks having characters’ names? This is kinda weird if you ask me.
Difficulty: 4/10
The bloody lust stacks are ridiculous. If you don’t end off on like +8 damage, you probably deserve an award!
Unlock value: B
Free tinted rocks, skulls, pots, and more! Kinda awkward to use, but never a bad take.
Azazel: The nail
Difficulty: 3/10
Azazel is op early game, and this is no exception. Only potential issues could be death or bloat (f@ck bloat).
Unlock value: C
A bunch of random and awkward 1-room buffs piled into one item, plus half a black heart. This feels like a filler item if you ask me.
Lazarus: MISSINGNO
Difficulty: 5/10
Only putting Lazarus higher than Isaac coz it could be hard if you have become Lazarus risen prior to entering (voluntarily or not!)
Unlock value: e
God this item sux! Just let me keep my build for 5 minutes!
Eden: UNDEFINED
Difficulty: 4/10
Depends heavily on the start of the run, but shouldn’t be too hard.
Unlock value: B
Easy access to IAMERROR rooms, what’s not to like?
The Lost: D100
Difficulty: 8/10
PAIN. LOTS OF PAIN.
Unlock value: C
For when you want to tell your current run to go screw itself!
Lilith: Immaculate conception
Difficulty: 6/10
Rock layouts can be a nightmare, but only if you don’t have spectral.
Unlock value: A
It gives holy water, relic, and 2 orbitals. better to get earlier in a run rather than later.
Keeper: Sticky nickels
Difficulty: 7/10
Keeper struggles coz his survivability is horrid. not complaining about wooden nickel, but it’s a tad inconsistent.
Unlock value: F
WHY IS THIS AN UNLOCK? IT ACTIVELY MAKES THE GAME WORSE!
Apollyon: Locust of conquest
Difficulty: 5/10
Isaac but with void, next!
Unlock value: B
Definitely a better trinket than Isaac’s head, but again, the competition can beat it out just barely.
The forgotten: Divorce papers
Difficulty: 4/10
The dual health bars allow for variation in playstyle and the bone club can take out basement bosses real fast.
Unlock value: B
It’s a boss pool unlock, but a damn good one at that.
Bethany: Beth’s faith
Difficulty: 3/10
BoV is just as good for the boss rush as BoB. just spam out wisps and take basically no damage.
Unlock value: C
Same boat as Isaac’s head, but the wisps can be useful all the way until delirium, also wtf the names are back!
Jacob and Esau: Rock Bottom
Difficulty: 8/10
JandE is painful to play as, especially here due to the onslaught of bosses with little health to boot.
Unlock Value: S
Yes, I know rock bottom is overhyped to some degree, but that doesn’t mean it isn’t an absolutely great item!
That's everything we are sharing today for this The Binding of Isaac: Rebirth guide. This guide was originally created and written by M1DKN1GH7. In case we fail to update this guide, you can find the latest update by following this link.